Fluid Air's® DuraGran™ Method

The proprietary DuraGran method, which received a patent in April of 2007, produces a significantly smaller amount of coarse material and considerably smaller amount of fines in comparison to the traditional method of granulating. For many of the newer compounds, the smaller size granule produced by this method is both desirable and achievable. Dissolution tests were performed on tablets compressed by the traditional and DuraGran methods for Granulation E. The tests show essentially the same results conforming to USP 27 Stage 1 Dissolution.

The data also demonstrates that the DuraGran method produces a more uniform granulation for material targeted to match a typical granulation for tablet compressing, and that it can be controlled to produce smaller and larger granules shifting the mean particle size of the granulation.

Fluid Air's PharmPro® Division pilot facility conducted many trial runs on various combinations of ingredients and binders using the DuraGran method which is based on a variation of the normal wet granulation process to produce granulations which would be typical for tabletting.

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